Home Page of Linda J. S. Allen


National Science Foundation GRANT
Collaborative Research: Modeling Immune Dynamics of RNA Viruses In Reservoir and Nonreservoir Species

NSF-1517719


Investigators at Texas Tech University:

  • Linda JS Allen, Texas Tech University
  • Alex Trindade, Texas Tech University


Graduate Students, Undergraduate Students, and Postdoctoral Fellows at Texas Tech University

  • Krystin E Steelman Huff, PhD student, Graduated May 2018
  • Aadrita Nandi, PhD student, Graduated August 2019
  • William Tritch, MS student, Graduated Fall 2016
  • Manjari Dissanayake, PhD Student, Graduated December 2018
  • Annabel Offer Meade, MS Student, Graduated Summer 2017
  • Fan Bai, Postdoctoral Fellow, 2016-2018.
  • Yu Jung Nam, Undergraduate Student, 2018-2019.
  • Kaniz Fatema Nipa, PhD student, Graduated August 2020


Collaborators:

  • Colleen Jonsson, University of Tennessee Health Science Center, Memphis TN
  • Michele Kosiewicz, University of Louisville


Graduate Students at University of Tennessee Health Science Center

  • Evan Williams, PhD student


Publications:
  • DG Goodin, CB Jonsson, LJS Allen, and RD Owen. 2018. Integrating landscape hierarchies in the discovery and modeling of ecological drivers of zoonotically transmitted disease from wildlife. In: The Connections Between Ecology and Infectious Disease, Book Series: Advances in Environmental Microbiology. C J. Hurst (Ed.) Springer
  • W Tritch and LJS Allen. 2018. Duration of a minor epidemic. Infectious Disease Modelling. 3: 60-73.
  • W Zhang, S Jang, C Jonsson, and LJS Allen. 2018. Models of cytokine dynamics in the inflammatory response in viral zoonotic infectious diseases. Mathematical Medicine and Biology. Accepted. doi: 10.1093/imammb/dqy009
  • F Bai, KES Huff, and LJS Allen. 2019. The effect of delay in viral production in within-host models during early infection. Journal of Biological Dynamics. 13: sup1, 47-73.
  • F Bai and LJS Allen. 2019. Probability of a major infection in a stochastic within-host model with multiple stages. Applied Mathematics Letters. 87: 1-6.
  • F Bai. 2019. Modeling vaccination decision making process in a finite population. Mathematical Biosciences. 311: 82-90.
  • A Nandi and LJS Allen. 2019. Stochastic two-group models with transmission dependent on host infectivity or susceptibility. Journal of Biological Dynamics. 13: sup1, 201-224.
  • A Nandi and LJS Allen. 2019. Stochastic multigroup epidemic models: duration and final size. IMA Volume for Ecological and Biological Systems, Springer. pp. 483-507.
  • M Dissanayake and A Trindade. 2020. An empirical saddlepoint approximation method for producing smooth survival and hazard functions under interval-censoring. 39(21): 2755-2766.
  • KF Nipa and LJS Allen. 2020. Disease Emergence in Multi-Patch Stochastic Epidemic Models with Demographic and Seasonal Variability. Bulletin of Mathematical Biology. 82:152 https://doi.org/10.1007/s11538- 020-00831-x (30 pages).
  • A Nandi and LJS Allen. 2021. Probability of a Zoonotic Spillover with Seasonal Variation. Infectious Disease Modelling. 6: 514-531.

Theses/Dissertations:
  • A Meade. Within-Host Models for Hantavirus Immune Response. Master's Report, TTU, M.S. August 2017.
  • KES Huff. Modeling the Early Stages of Within-Host Infection and Clinical Progression of Hantavirus Pulmonary Syndrome. PhD. May 2018.
  • M Dissanayake. An Empirical Saddlepoint Approximation Method for Smoothing Survival Functions Under Interval-Censoring and Classification of C Elegans using Functional Data Analysis Methods. PhD. December 2018.
  • A Nandi. Stochastic Models of Emerging or Re-emerging Infectious Diseases: Probability of Outbreak, Duration and Final Size. PhD. August 2019.
  • KF Nipa. Effects of Demographic, Environmental and Seasonal Variability on Disease Outbreaks in Stochastic Vector-host, Multi-patch and Dengue Epidemic Models. Co-Chair: Sophia Jang. PhD. August 2020.

Presentations/Posters:
  • Poster: "Modeling Innate Immune Response: Hantavirus in Reservoir/Nonreservoir Hosts". A Offer-Meade. Xth International Conference on HFRS, HPS, and Hantaviruses, Fort Collins, CO, May 31-June 3, 2016.
  • Presentation: "Duration of a Minor Epidemic Near the Critical Threshold of R_0=1". LJS Allen. Joint Mathematics Meetings, Session: Advances in Mathematics of Ecology, Epidemiology and Immunology of Infectious Diseases, Atlanta, Georgia, January 5-7, 2017.
  • Presentation: "Modeling the Early Stages of a Within-Host Viral Infection". KE Steelman. 97th Annual Meeting of the MAA Texas Section, Texas A&M University-Commerce, March 31-April 1, 2017.
  • Presentation: "Modeling the Early Stages of a Within-Host Viral Infection". KE Steelman. West Texas Applied Math Graduate Minisymposium, Texas Tech University, April 28, 2017.
  • Presentation: "Environment, Host and Pathogen Diversity on Probability of Disease Extinction". LJS Allen, BAMM 2017, Biology and Medicine Through Mathematics Conference, Virginia Commonwealth University, May 18-20, 2017.
  • Presentation: "Mathematical Modeling of Viral Zoonotic Infectious Diseases". LJS Allen. University of Kelaniya, Mathematics Colloquium, Sri Lanka, July 14, 2017.
  • Poster: "Within-host Mathematical Models for Orthohantavirus Infections". A Adams, O Dougherty, Q Murphy. MBI Summer Undergraduate Capstone Conference, Ohio State University, August 7-11, 2017.
  • Presentation: "Probability of Outbreak and Time to Outbreak in Viral Zoonotic Infectious Diseases". LJS Allen, PIMS-UVic Distinguished Lecture. University of Victoria, September 21, 2017.
  • Presentation "The Duration of a Minor Epidemic in Stochastic Models of Infectious Diseases". LJS Allen, ICMA VI, University of Arizona, October 20, 2017.
  • Presentation: "Stochastic Models on the Emergence of Disease in Viral Zoonoses". LJS Allen, Biomathematics Seminar, Arizona State University, October 19, 2017.
  • Presentation: "The Effect of Delay in Viral Production in Within-Host Models during Early Infection". F Bai, ICMA VI, University of Arizona, October 21, 2017.
  • Poster: "Modeling the Early Clinical Progression of Hantavirus Pulmonary Syndrome". KES Huff, ICMA VI, University of Arizona, October 20, 2017.
  • Presentation: "Stochastic Models of Within-Host Viral Infection". KES Huff, Joint Math Meetings, San Diego, CA, January 12, 2018.
  • Presentation: "Probability of a Major Infection in a Stochastic Within-Host Model for a Viral Infection with Multiple Latent and Infectious Stages". F Bai. Frontiers in Mathematical Biology, May 2-4, 2018.
  • Presentation: "The Probability and Duration of Epidemic in Stochastic MultiStage and MultiGroup Models". LJS Allen, Institute for Mathematics and its Applications, Ecological and Biological Systems Workshop, June 4-8, 2018.
  • Presentation: "Probability of and Time to Spillover and Extinction in Infectious Diseases", A Nandi, SIAM Life Sciences 2018, Minneapolis Minnesota, August 2018.
  • Presentation: "Probability, Duration and Final Size of an Epidemic in Multistage and Multigroup Models", LJS Allen, Invited Colloquium at Center for Modeling Complex Interactions, University of Idaho, August 30,2018.
  • Presentation: "Effects of Host Infectivity and Susceptibility on Disease Emergence in Stochastic Multigroup Models with Applications to Emerging and Re-emerging Infectious Diseases" A Nandi, First Annual meeting SIAM Texas-Louisiana Section, Lousiana State University, Baton Rouge, LA, October 5-7, 2018.
  • Presentation: "Extinction Thresholds in Stochastic Epidemic Models with Periodic Environments", LJS Allen, AMS Western Sectional Meeting, San Francisco, CA, October 27-28, 2018.
  • Presentation: "Probability, Final Size, and Duration of an Outbreak in Stochastic Multigroup Models", A Nandi, Joint Mathematics Meetings 2019, Baltimore, Maryland, January 16-19, 2019.
  • Presentation: "The Impact of Demographic and Environmental Variability on Disease Emergence in Stochastic Epidemic Models", LJS Allen, Computational and Mathematical Population Dynamics 5, Fort Lauderdale, Florida, Plenary Talk, May 21, 2019.
  • Presentation: "Stochastic Models of Emerging and Re-Emerging Diseases", A Nandi, Computational and Mathematical Population Dynamics 5, Bahai Mar, Fort Lauderdale, Florida, May 22, 2019.
  • Presentation: "Stochastic Epidemic Model for Zoonotic Spillover", LJS Allen, Society for Mathematical Biology Annual Conference, Universite de Montreal, Quebec, Canada, July 22, 2019.
  • Poster: "Modeling the Immune Response for Pathogenic and Nonpathogenic Orthohantavirus Infections of Human Endothelial Cells", YJ Nam and A Nandi, North Carolina State University, Tutorial Workshop on Parameter Estimation for Biological Models, July 29-August 1, 2019.
  • Presentation: "Stochastic Epidemic Models of Zoonotic Spillover", LJS Allen, BioHasard 2019 International Conference on Stochastic Models for Biology, Universite de Rennes, France, August 26-29, 2019.
  • Presentation: "Probability of a Zoonotic Spillover", LJS Allen, ICMA VII, Arizona State University, October 2019.
  • Presentation: "Seasonal Variability on Disease Outbreaks in Stochastic Multi-Patch Epidemic Models". University of Central Florida, Invited Virtual Colloquium, October 30, 2020.
  • AMS-MAA Invited Address: "Modeling of Viral Zoonotic Infectious Diseases from Wildlife to Humans". Online Joint Mathematics Meetings 2021, January 8, 2021.
  • Presentation: "Disease Emergence in Multi-Patch Stochastic Epidemic Models with Demographic and Seasonal Variability", Midwest Mathematical Biology Seminar, University of Minnesota, February 15, 2021.
  • Presentation: "Disease Emergence in Multi-Patch Stochastic Epidemic Models with Demographic and Seasonal Variability", Online Math/Bio Seminar, Washington State University, February 16, 2021.
  • Presentation: "Zoonotic Spillover in Stochastic Epidemic Models with Demographic and Seasonal Variability", Mathematics Colloquium, University of Pittsburgh, April 2, 2021.

"Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation."


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